abstract：:In schizophrenia, four typical patterns of premorbid functioning have been observed: stable-good, stable-intermediate, poor-deteriorating and deteriorating. However, it is unknown whether similar patterns exist in those who are at clinical high risk (CHR) of psychosis. The aim of this study was to examine patterns of ...

journal_title：Schizophrenia research

authors： Lyngberg K,Buchy L,Liu L,Perkins D,Woods S,Addington J

更新日期：2015-12-01 00:00:00

abstract：:Negative symptoms can be grouped into the two dimensions of diminished expression and apathy, which have been shown to be dissociable regarding external validators, such as functional outcome. Here, we investigated whether these two dimensions differentially relate to neurocognitive impairment in schizophrenia. 47 pat...

journal_title：Schizophrenia research

authors： Hartmann-Riemer MN,Hager OM,Kirschner M,Bischof M,Kluge A,Seifritz E,Kaiser S

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Studies show that deficit syndrome schizophrenia patients, characterized by primary negative symptoms and poor functional outcome, have impairment in specific neural circuits. We assessed whether these same neural circuits are directly linked to functional outcomes across schizophrenia patients. METHODS:T1- an...

journal_title：Schizophrenia research

authors： Behdinan T,Foussias G,Wheeler AL,Stefanik L,Felsky D,Remington G,Rajji TK,Mallar Chakravarty M,Voineskos AN

更新日期：2015-12-01 00:00:00

abstract：:The nucleus accumbens (NAcc) is often implicated in schizophrenia (SZ) pathology, but with little evidence to support its role. This study examined postmortem human tissue to determine if abnormalities are present in the dopaminergic or glutamatergic systems in the NAcc in SZ. We compared the protein levels of tyrosin...

journal_title：Schizophrenia research

authors： McCollum LA,Roberts RC

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that individuals with schizophrenia exhibit higher levels of unhelpful metacognitive beliefs than healthy controls, but no studies have explored metacognitive beliefs in early psychosis. AIMS:We examined i) differences in levels of unhelpful metacognitive beliefs between psychosi...

journal_title：Schizophrenia research

authors： Østefjells T,Melle I,Hagen R,Romm KL,Sönmez N,Andreassen OA,Røssberg JI

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Older paternal age predicts schizophrenia diagnosis in offspring. If this relationship reflects a pathogenic process, paternal age should predict the expression of subclinical schizophrenia liability (schizotypy). We hypothesized that paternal and maternal ages predict positive, negative, and disorganized fe...

journal_title：Schizophrenia research

authors： Grattan RE,Morton SE,Warhurst ES,Parker TR,Nicolson MP,Maha JLK,Linscott RJ

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:The main goal of the present study was to analyze levels of cytokines of the interleukin family (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8 and IL-10), interferon-gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP1), tumor necrosis factor-alpha (TNF-α), and vascular endothelial and endothelial growth factors (V...

journal_title：Schizophrenia research

authors： Haring L,Koido K,Vasar V,Leping V,Zilmer K,Zilmer M,Vasar E

更新日期：2015-12-01 00:00:00

abstract：:Schizophrenia is associated with significant impairments in both higher and lower order social cognitive performance and these impairments contribute to poor social functioning. People with schizophrenia report poor social functioning to be one of their greatest unmet treatment needs. Recent studies have suggested the...

journal_title：Schizophrenia research

authors： Guastella AJ,Ward PB,Hickie IB,Shahrestani S,Hodge MA,Scott EM,Langdon R

更新日期：2015-11-01 00:00:00

abstract：:The recalcitrance of negative symptoms in the face of pharmacologic treatment has spurred interest in understanding the psychological factors that contribute to their formation and persistence. Accordingly, this study investigated whether deficits in metacognition, or the ability to form integrated ideas about oneself...

journal_title：Schizophrenia research

authors： Lysaker PH,Kukla M,Dubreucq J,Gumley A,McLeod H,Vohs JL,Buck KD,Minor KS,Luther L,Leonhardt BL,Belanger EA,Popolo R,Dimaggio G

更新日期：2015-10-01 00:00:00

abstract：:Evidence validating the influence of the cytochrome P450 (CYP) 2D6 and 2C19 enzymes genetic polymorphisms in the response to antipsychotics is scarce. We examined the hypothesis that a higher prevalence of CYP2D6 and/or CYP2C19 ultra rapid metabolizers might be found among refractory schizophrenia patients. Three grou...

journal_title：Schizophrenia research

authors： van de Bilt MT,Prado CM,Ojopi EP,Sousa RT,Loch AA,Zanetti MV,Talib LL,Gattaz WF

更新日期：2015-10-01 00:00:00

abstract：:Schizophrenia (SZ) is a mental illness characterized by psychosis, negative symptoms, and cognitive deficits. The anterior cingulate cortex (ACC), a structurally and functionally diverse region, is one of several brain regions that is abnormal in SZ. The present study compared synaptic organization and mitochondrial n...

journal_title：Schizophrenia research

authors： Roberts RC,Barksdale KA,Roche JK,Lahti AC

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Persistent formal thought disorder (FTD) is one of the most characteristic features of schizophrenia. Several neuroimaging studies report spatially distinct neuroanatomical changes in association with FTD. Given that most studies so far have employed a univariate localisation approach that obscures the study...

journal_title：Schizophrenia research

authors： Palaniyappan L,Mahmood J,Balain V,Mougin O,Gowland PA,Liddle PF

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:All currently available antipsychotic medications bind to both the dopamine-2 (D2) and dopamine-3 (D3) receptors in vitro. However, there is conflicting evidence from in vivo studies about whether or not antipsychotic medications bind to the D3 receptor (D3R). The purpose of this study was to determine wheth...

journal_title：Schizophrenia research

authors： Girgis RR,Xu X,Gil RB,Hackett E,Ojeil N,Lieberman JA,Slifstein M,Abi-Dargham A

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Bullying victimisation has been suggested to contribute to paranoid ideation in general population samples and recent evidence found that individuals with an ultra high risk (UHR) for psychosis are twice as likely to have been bullied than controls. AIMS:This study sought to examine whether a history of bul...

journal_title：Schizophrenia research

authors： Valmaggia LR,Day FL,Kroll J,Laing J,Byrne M,Fusar-Poli P,McGuire P

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Many studies have identified urban-rural differences in the occurrence of schizophrenia. Though unknown, the underlying causes responsible for these differences have been hypothesized to include urban-rural differences in toxic exposures, diet, infections, stress, or an artifact due to selective migration. F...

journal_title：Schizophrenia research

authors： Pedersen CB

更新日期：2015-10-01 00:00:00

abstract：:The involvement of the gamma-aminobutyric acid (GABA) system in schizophrenia is suggested by postmortem studies and the common use of GABA receptor-potentiating agents in treatment. In a recent study, we used a benzodiazepine challenge to demonstrate abnormal GABAergic function during processing of negative visual st...

journal_title：Schizophrenia research

authors： Tso IF,Fang Y,Phan KL,Welsh RC,Taylor SF

更新日期：2015-10-01 00:00:00

abstract：:Grey matter brain networks are disrupted in schizophrenia, but it is still unclear at which point during the development of the illness these disruptions arise and whether these can be associated with behavioural predictors of schizophrenia. We investigated if single-subject grey matter networks were disrupted in a sa...

journal_title：Schizophrenia research

authors： Tijms BM,Sprooten E,Job D,Johnstone EC,Owens DG,Willshaw D,Seriès P,Lawrie SM

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Formal thought disorder (FTD) is a core feature of psychosis, however there are gaps in our knowledge about its prevalence and factor structure. We had two aims: first, to establish the factor structure of FTD; second, to explore the clinical utility of dimensions of FTD in order to further the understanding...

journal_title：Schizophrenia research

authors： Roche E,Lyne JP,O'Donoghue B,Segurado R,Kinsella A,Hannigan A,Kelly BD,Malone K,Clarke M

更新日期：2015-10-01 00:00:00

abstract：:Postmortem studies have suggested that there is abnormal GABAergic activity in the hippocampus in schizophrenia (SZ). In micro-dissected human hippocampal slices, a loss of interneurons and a compensatory upregulation of GABAA receptor binding activity on interneurons, but not PNs, has suggested that disinhibitory GAB...

journal_title：Schizophrenia research

authors： Benes FM

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Our previous lipidomics studies demonstrated elevated sulfatides, plasmalogens, and N-acylphosphatidylserines in the frontal cortex of schizophrenia subjects. These data suggest that there may be an abnormal function of glycosynapses in schizophrenia. We further examined the disease and anatomical specificit...

journal_title：Schizophrenia research

authors： Wood PL,Holderman NR

更新日期：2015-08-01 00:00:00

abstract：:It is now well established that the utilization of standardized clinical criteria can enhance prediction of psychosis. These criteria are primarily concerned with the presence and severity of attenuated positive symptoms. Because these symptom criteria are used to derive algorithms for designating clinical high risk (...

journal_title：Schizophrenia research

authors： Waford RN,MacDonald A,Goines K,Novacek DM,Trotman HD,Elaine F W,Addington J,Bearden CE,Cadenhead KS,Cannon TD,Cornblatt BA,Heinssen R,Mathalon DH,Tsuang MT,Perkins DO,Seidman LJ,Woods SW,McGlashan TH

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Activated immune-inflammatory pathways play an important role in the pathophysiology of schizophrenia. Paraoxonase 1 (PON1) activity is inversely associated with inflammatory responses in numerous clinical conditions. The aims of this study were to delineate serum arylesterase PON1 activity in drug-naïve fir...

journal_title：Schizophrenia research

authors： Brinholi FF,Noto C,Maes M,Bonifácio KL,Brietzke E,Ota VK,Gadelha A,Cordeiro Q,Belangero SI,Bressan RA,Vargas HO,Higachi L,de Farias CC,Moreira EG,Barbosa DS

更新日期：2015-08-01 00:00:00

abstract：:This is the first study to investigate whether positive family history (FH) of psychosis and affective disorders moderates the relationship between child diagnostic status and parent-reported social and behavioral problems on the Child Behavior Checklist (CBCL) in clinical high-risk adolescents. This longitudinal inve...

journal_title：Schizophrenia research

authors： Simeonova DI,Lee FJ,Walker EF

更新日期：2015-08-01 00:00:00

abstract：:Fragile X mental retardation protein (FMRP) is an RNA binding protein with 842 target mRNAs in mammalian brain. Silencing of the fragile X mental retardation 1 (FMR1) gene leads to loss of expression of FMRP and upregulated metabotropic glutamate receptor 5 (mGluR5) signaling resulting in the multiple physical and cog...

journal_title：Schizophrenia research

authors： Folsom TD,Thuras PD,Fatemi SH

更新日期：2015-07-01 00:00:00

abstract：:In the last 25 years, the Positive and Negative Syndrome Scale (PANSS) has been largely used to assess schizophrenia symptom intensity, but little information is available on how this scale was generally applied when evaluating the efficacy of schizophrenia therapies in randomized clinical trials. In the attempt to ad...

journal_title：Schizophrenia research

authors： Nicotra E,Casu G,Piras S,Marchese G

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:Frontal hypoactivation has been consistently found in schizophrenia. We hypothesized that patients' deficit is asymmetrical, i.e., centred over the left frontal locations, associated with loss of language-related asymmetry, and correlated with positive symptoms. METHOD:The amplitude of EEG gamma band (36-48...

journal_title：Schizophrenia research

authors： Spironelli C,Angrilli A

更新日期：2015-06-01 00:00:00

abstract：:Psychotic experiences are far more common in the population than psychotic disorder. They are associated with a number of adverse outcomes but there has been little research on associations with functioning and distress. We wished to investigate functioning and distress in a community sample of adolescents with psycho...

journal_title：Schizophrenia research

authors： Kelleher I,Wigman JT,Harley M,O'Hanlon E,Coughlan H,Rawdon C,Murphy J,Power E,Higgins NM,Cannon M

更新日期：2015-06-01 00:00:00

abstract：:Two previous studies suggested that childhood cat ownership is a possible risk factor for later developing schizophrenia or other serious mental illness. We therefore used an earlier, large NAMI questionnaire to try and replicate this finding. The results were the same, suggesting that cat ownership in childhood is si...

journal_title：Schizophrenia research

authors： Fuller Torrey E,Simmons W,Yolken RH

更新日期：2015-06-01 00:00:00

abstract：:Evidence suggests that insight in psychosis has been related to treatment adherence, recovery and good prognosis, but also to depression, low self-esteem, and diminished quality of life. Thus, insight might not be advantageous under all circumstances. Internalized-stigma (i.e. self-acceptance of stigmatizing images of...

journal_title：Schizophrenia research

authors： Valiente C,Provencio M,Espinosa R,Duque A,Everts F

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Blockade of dopamine D₂ receptors with antipsychotics above 65% is associated with optimal chance of clinical response although recent data suggest a lower threshold for the maintenance treatment of schizophrenia. The objective of this study was to prospectively examine whether such continuous high blockade w...

journal_title：Schizophrenia research

authors： Tsuboi T,Suzuki T,Bies RR,Remington G,Pollock BG,Mimura M,Uchida H

更新日期：2015-05-01 00:00:00

abstract：:The objective of this study was to evaluate the efficacy, safety and tolerability of brexpiprazole versus placebo in adults with acute schizophrenia. This was a 6-week, multicenter, placebo-controlled double-blind phase 3 study. Patients with acute schizophrenia were randomized to brexpiprazole 1, 2 or 4 mg, or placeb...

journal_title：Schizophrenia research

authors： Kane JM,Skuban A,Ouyang J,Hobart M,Pfister S,McQuade RD,Nyilas M,Carson WH,Sanchez R,Eriksson H

更新日期：2015-05-01 00:00:00

abstract：:Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and exhibit qualities of endophenotypes, including substantial heritability, test-retest reliability, and trait-like stability. These measures also fulfill criteria for use a...

journal_title：Schizophrenia research

authors： Light GA,Swerdlow NR,Thomas ML,Calkins ME,Green MF,Greenwood TA,Gur RE,Gur RC,Lazzeroni LC,Nuechterlein KH,Pela M,Radant AD,Seidman LJ,Sharp RF,Siever LJ,Silverman JM,Sprock J,Stone WS,Sugar CA,Tsuang DW,Tsuang MT

更新日期：2015-04-01 00:00:00

abstract：:The first phase of the Consortium on the Genetics of Schizophrenia (COGS-1) showed performance deficits in learning and memory on the California Verbal Learning Test, Second Edition (CVLT-II) in individuals with schizophrenia (SZ), compared to healthy comparison subjects (HCS). A question is whether the COGS-1 study, ...

journal_title：Schizophrenia research

authors： Stone WS,Mesholam-Gately RI,Braff DL,Calkins ME,Freedman R,Green MF,Greenwood TA,Gur RE,Gur RC,Lazzeroni LC,Light GA,Nuechterlein KH,Olincy A,Radant AD,Siever LJ,Silverman JM,Sprock J,Sugar CA,Swerdlow NR,Tsuang DW

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Diffusion tensor imaging (DTI) studies in patients with schizophrenia have shown abnormalities in the microstructure of white matter tracts. Specifically, reduced fractional anisotropy (FA) has been described across multiple white matter tracts, in studies that have mainly included patients treated with an...

journal_title：Schizophrenia research

authors： Alvarado-Alanis P,León-Ortiz P,Reyes-Madrigal F,Favila R,Rodríguez-Mayoral O,Nicolini H,Azcárraga M,Graff-Guerrero A,Rowland LM,de la Fuente-Sandoval C

更新日期：2015-03-01 00:00:00

abstract：:Schizophrenia is a severe psychiatric disorder with lifetime prevalence of ~1% worldwide. A genotyping study was conducted using a custom panel of Illumina 1536 SNPs in 840 schizophrenia cases and 876 controls (351 patients and 385 controls from North India; and 436 patients, 401 controls and 143 familial samples with...

journal_title：Schizophrenia research

authors： Jajodia A,Kaur H,Kumari K,Gupta M,Baghel R,Srivastava A,Sood M,Chadda RK,Jain S,Kukreti R

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Several risk factors of venous thromboembolism (VTE) and pulmonary embolism (PE) were found in patients with schizophrenia. Therefore, we hypothesize that the incidences of VTE and PE are relatively higher among schizophrenia patients in comparison with the general population. METHOD:For this population-base...

journal_title：Schizophrenia research

authors： Hsu WY,Lane HY,Lin CL,Kao CH

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:White matter (WM) abnormalities are one of the most widely and consistently reported findings in schizophrenia (SZ) and bipolar disorder (BD). If these abnormalities are inherited determinants of illness, suitable to be classified as an endophenotype, relatives of patients must also have them at higher rate ...

journal_title：Schizophrenia research

authors： Arat HE,Chouinard VA,Cohen BM,Lewandowski KE,Öngür D

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:The primary aim is to examine concordant/discordant results of drug use assessments in adults with schizophrenia. METHODS:Latent class analysis and multinomial logistic regression were used to examine concordance/discordance between drug use measures and identify characteristics differentiating participants ...

journal_title：Schizophrenia research

authors： Johnson KL,Desmarais SL,Swartz MS,Van Dorn RA

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:The comparative antidepressant effects of clozapine and other atypical antipsychotics for schizophrenia remain elusive, leading us to examine this question using the data from the Clinical Antipsychotic Trials of Intervention Effectiveness phase 2E. METHODS:Ninety-nine patients who discontinued treatment wi...

journal_title：Schizophrenia research

authors： Nakajima S,Takeuchi H,Fervaha G,Plitman E,Chung JK,Caravaggio F,Iwata Y,Mihashi Y,Gerretsen P,Remington G,Mulsant B,Graff-Guerrero A

更新日期：2015-02-01 00:00:00

abstract：:Atypical antipsychotic drugs (AAPDs) are widely used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent rats with...

journal_title：Schizophrenia research

authors： Xu S,Gullapalli RP,Frost DO

更新日期：2015-02-01 00:00:00